发明名称 |
Charge reversal of polyion complexes |
摘要 |
An ionic polymer is utilized in "recharging" (another layer having a different charge) a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The resulting recharged complex can be formed with an appropriate amount of positive or negative charge such that the resulting complex has the desired net charge.
|
申请公布号 |
US7396919(B1) |
申请公布日期 |
2008.07.08 |
申请号 |
US19990328975 |
申请日期 |
1999.06.09 |
申请人 |
MIRUS BIO CORPORATION |
发明人 |
WOLFF JON A.;TRUBETSKOY VLADIMIR S.;LOOMIS AARON G.;SLATTUM PAUL M.;MONAHAN SEAN D.;HAGSTROM JAMES E.;BUDKER VLADIMIR G. |
分类号 |
C07H21/04;A61K47/48;A61K48/00;C12N15/00;C12N15/87 |
主分类号 |
C07H21/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|