2-(METHYLTHIO)PYRIMIDINE DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

摘要

2-(Methylthio)pyrimidine derivatives are provided to inhibit growth of hepatitis C virus and minimize toxicity and side effects, so that the compounds are useful for prevention and treatment of hepatitis C. The 2-(methylthio)pyrimidine derivatives represented by the formula(1) and pharmaceutically acceptable salts thereof inhibit growth of hepatitis C virus, wherein R1 is hydrogen, hydroxyl group, -N(R2)-(CH2)-R3 group, 4-(R4)-(Het)-1-yl group or -(CH2)n-R5 group; R2 is hydrogen or C1-C4 linear or branched alkyl group; R3 is hydrogen, halogen atom, hydroxyl group, isopropyl group, C2-C6 linear or branched dialkylamino group, C1-C4 linear or branched alkoxy group, C3-C6 cycloalkyl group or C3-C6 heterocyclic ring optionally substituted by C1-C4 linear or branched alkyl group; (Het) is piperidine or piperazine; R4 is hydrogen, hydroxyl group, carbamoyl group, acetyl group, acetamido group, C1-C4 linear or branched alkyl group, C1-C4 linear or branched hydroxyalkyl group, C1-C4 alkyl group substituted by C1-C4 alkoxy group, C1-C4 alkyl group substituted by morpholino group, phenyl group substituted by hydroxyl group, or C3-C6 heterocyclic ring containing nitrogen atom; R5 is C3-C6 heterocyclic group; and n is an integer from 0 to 4.