Urea derivative, medicinal composition containing the same, and medicinal use of these

摘要

Urea derivatives represented by the following general formula (I): which have an agonism of V2 receptor, are useful as agents for the treatment or prevention of diabetes insipidus, nocturia, nocturnal enuresis, overactive bladder or the like. In the formula, R¹ represents a hydrogen atom or a C_1-6 alkyl group which may have a substituent, R² is a hydrogen atom or a C_1-6 alkyl group, R³ is a hydrogen atom, a C_1-6 alkyl group or the like, R⁴, R⁵ and R⁶ are independently a hydrogen atom, a halogen atom or the like, R⁷ is a hydrogen atom, a heteroaryl group which may have a substituent, a C_3-8 cycloalkyl group, an amino group which may have a substituent or a C_1-6 alkoxy group which may have a substituted group, M¹ is a single bond, a C_1-4 alkylene group or the like, Y is N or CR^F (in the formula, and R^F represents a hydrogen atom, a C_1-6 alkyl group or the like, or pharmaceutically acceptable salts thereof, or prodrugs thereof, or pharmaceutical compositions comprising the same and pharmaceutical uses thereof.