DEVICES AND METHODS FOR INHIBITING FIBROSIS

摘要

The present invention relates to compositions and methods for rendering medical devices less prone to fibrous encapsulation comprising the use of non-gaseous CO dissolved in a reservoir material. Upon exposure to a biological environment, non-gaseous CO is slowly desorbed and/or dissolved from the reservoir material which provides anti-fibrotic activity. These compositions and methods may be used directly on soft tissue implants and/or medical devices to treat and/or prevent conditions and disease states related to fibrosis. Furthermore, the compositions can be incorporated into materials that are used to create soft tissue implants and/or medical devices to imbue implants and devices with anti-fibrotic properties.