COMPOSITION OF AND METHOD FOR PREPARING ORALLY DISINTEGRATING TABLETS CONTAINING A HIGH DOSE OF PHARMACEUTICALLY ACTIVE INGREDIENTS

摘要

The present invention is directed to improved compositions and methods fo r preparing orally disintegrating tablets (ODTs). In one aspect of the prese nt invention, the ODT further contains at least one active pharmaceutical in gredient (API). In another aspect of the present invention, the ODT contains a high load of at least one API. Specifically, the ODTs described in this i nvention containing a high load of API can accommodate up to about 70% w/w o f active pharmaceutical ingredient in a unit dosage, while exhibiting the de sirable attributes of fast disintegration time, acceptable hardness and fria bility for push through blister and bottle packages, and acceptable mouth fe el.