| 发明名称 |
ANTI-APOPTOTIC PROTEIN ANTIBODIES |
| 摘要 |
<p>Single-domain anti-bodies that bind pro-apoptotic proteins Bax and caspase-3 are identified and isolated. These single-domain antibodies may be used to modulate the active of Bax and caspase-3, thereby modulating the symptoms and steps of oxidative stress and/or cell apoptosis, including Bax dimerization, mitochondrial permeabilization and the release of apoptotic proteins.</p> |
| 申请公布号 |
EP1937814(A2) |
申请公布日期 |
2008.07.02 |
| 申请号 |
EP20060790628 |
申请日期 |
2006.09.01 |
| 申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA;UNIVERSITY OF WINDSOR |
发明人 |
PANDEY, SIYARAM;TANHA, JAMSHID;GUEORGUIEVA, DEYZI |
| 分类号 |
C12N15/13;A61K39/395;A61K47/44;A61K47/48;A61K48/00;A61P35/00;C07K16/18;C07K16/40;C07K17/00;C12N1/21;C12N5/10;C12N9/48;C12N15/86 |
主分类号 |
C12N15/13 |
| 代理机构 |
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