发明名称 |
SULFONAMIDE DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY |
摘要 |
The present invention provides an sulfonamide derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. A compound of the general formula (II):
wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the ring C is an aromatic carbocyclic ring etc.; R1 is carboxy etc.; R2 is independently a halogen atom etc.; R3 is optionally substituted alkyloxy etc.; R4 is independently a halogen atom etc.; R5 is independently optionally substituted alkyl etc.; M is sulfonyl etc.; Y is a single bond etc.; L1 is a single bond etc.; L2 is a single bond etc.; k is 0, 1, 2, 3 or 4; n is 0, 1 or 2; and q is 0, 1, 2 or 3; provided that a) k is not 0 when the ring B is a 6-membered nitrogen-containing heterocyclic ring containing one or two nitrogen atom(s) and the ring C is a benzene ring, etc.;
a pharmaceutically acceptable salt or a hydrate thereof. |
申请公布号 |
EP1939175(A1) |
申请公布日期 |
2008.07.02 |
申请号 |
EP20060810485 |
申请日期 |
2006.09.25 |
申请人 |
SHIONOGI&CO., LTD. |
发明人 |
KUGIMIYA, AKIRA;FUJIOKA, MASAHIKO;TACHIBANA, YUKI;MURASHI, TAKAMI;ONODERA, NAOHIRO |
分类号 |
C07D207/48;A61K31/40;A61K31/445;A61K31/451;A61K31/4545;A61K31/495;A61K31/496;A61P11/06;A61P37/08;A61P43/00;C07D207/14 |
主分类号 |
C07D207/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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