发明名称 |
Diagnosis and treatment of cancer: I |
摘要 |
A method of diagnosing cancer comprising the steps of (i) obtaining a sample containing nucleic acid and/or protein from the patient; and (ii) determining whether the sample contains a level of SCN5A (and optionally also SCN9A) voltage-gated Na+ channel nucleic acid or protein associated with cancer. A method of diagnosing breast cancer comprising the steps of (i) obtaining a sample containing nucleic acid and/or protein from the patient; and (ii) determining whether the sample contains a level of voltage-gated Na+ channel nucleic acid or protein, preferably SCN5A or 5CN9A, associated with cancer. A method of treating cancer comprising the step of administering to the patient an agent which selectively prevents the function of SCN5A (and optionally also SCN9A) voltage-gated Na+ channel. A method of treating breast cancer comprising the step of administering to the patient an agent which selectively prevents the function of a voltage-gated Na+ channel, preferably SCN5A or 5CN9A. Genetic constructs and molecules useful in such methods. The methods and compositions are particularly suited to breast cancer.
|
申请公布号 |
US7393657(B2) |
申请公布日期 |
2008.07.01 |
申请号 |
US20040474778 |
申请日期 |
2004.03.04 |
申请人 |
IMPERIAL COLLEGE INNOVATIONS LIMITED |
发明人 |
DISS JAMES K. J.;COOMBES RAOUL C.;DJAMGOZ MUSTAFA B. A.;FRASER SCOTT P. |
分类号 |
G01N33/50;G01N33/574;A61K38/00;A61K47/48;A61K48/00;A61P35/00;C07K14/705;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12Q1/68;G01N33/15;G01N33/53;G01N33/566 |
主分类号 |
G01N33/50 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|