发明名称 |
SOLID DISPERSION COMPRISING A POORLY WATER SOLUBLE DRUG |
摘要 |
Pharmaceutical compositions comprising a poorly water soluble ionizable drug, a cationic species and a dispersion polymer are disclosed, together with a process for forming the compositions. The neutral form of the drug has (i) a solubility of less than 1 mg/mL in aqueous solution at a pH between 6 and 7, (ii) a solubility of less than 20 mg/mL in a volatile organic solvent, and (iii) an acidic pKa value of greater than 5. At least 90 wt% of the drug in the solid dispersion being in a non-crystalline form. The drug, the cationic species, and the dispersion polymer constitute at least 80 wt% of the solid dispersion. |
申请公布号 |
WO2008047201(A3) |
申请公布日期 |
2008.06.26 |
申请号 |
WO2007IB03062 |
申请日期 |
2007.10.08 |
申请人 |
PFIZER PRODUCTS INC.;KETNER, RODNEY JAMES;LORENZ, DOUGLAS ALAN;LYON, DAVID KEITH |
发明人 |
KETNER, RODNEY JAMES;LORENZ, DOUGLAS ALAN;LYON, DAVID KEITH |
分类号 |
A61K9/16;A61K31/437;A61K31/501;A61K31/522;C07D213/00;C07D405/00;C07D471/00;C07D473/00;C07D519/00 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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