5- [4- (AZETIDIN-3-YL0XY) -PHENYL] -2-PHENYL-5H-THIAZ0L0 [5,4-C] PYRIDIN-4-0NE DERIVATIVES AND THEIR USE AS MCH RECEPTOR ANTAGONISTS

摘要

The present invention relates to a melanin concentrating hormone antagoni st compound of formula I: wherein "-----" is absent or is optionally a bond; q is 1 or 2; R1 is independently selected from hydrogen, -C1-C2 alkyl, halo , hydroxy, -C1-C2 haloalkyl, -C1-C3 alkoxy, cyano, -O-C3-C4 cycloalkyl, and -OC1-C2 haloalkyl; R2 is selected from the group consisting of hydrogen, -C1 -C3 alkyl, hydroxy, -C1-C3 alkoxy, cyano, -C1-C2 haloalkyl, -OC1-C2 haloalky l, and halo; R3 is selected from the group consisting of hydrogen, -C1-C4 al kyl, -C2-C4 haloalkyl, -C2-C4 alkylOH, -C3-C6 cycloalkyl, -CH2C3-C6 cyxloalk yl, -C2-C4 alkyl-O-C1-C4 alkyl, -C(O)C1-C4 alkyl, -C(O)C1-C4 haloalkyl, -CH2 -thiazole, phenyl, benzyl, tetrahydrothiopyranyl, and tetrahydropyranyl, whe rein the cycloalkyl, tetrahydrothiopyranyl, tetrahydropyranyl and thiazolyl group is optionally substituted with one or two groups independently selecte d from the group consisting of halo, hydroxy, C1-C2 alkyl, and -C1-C2 haloal kyl; or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixt ure thereof,, useful in the treating, preventing or ameliorating of symptoms associated with obesity and related diseases.