发明名称 |
Method for treating ADAMTS-5-associated disease |
摘要 |
The present invention relates to methods of treating ADAMTS-5-associated diseases and particularly osteoarthritis comprising administering an agent capable of modulating ADMATS-5 activity to a subject afflicted with the disease. The agent is preferably a biaryl sulfonamide compound. The invention is based, in part, on the discovery that transgenic animals that do not express functional ADAMTS-5 show a reduction in the degree of osteoarthritis after the induction of osteoarthritis as compared to WT animals. Furthermore, the ADAMTS-5 transgenic animals have reduced aggrecanase activity in articular tissue as compared to WT animals. These animals are good models for ADAMTS-5-associated diseases, and for screening of drugs useful in the treatment and/or prevention of these diseases. There are no other animal models in which the deletion of the activity of a single gene is capable of abrogating the course of osteoarthritis. Accordingly, these animals also show that osteoarthritis can be prevented and/or treated by administering to a subject an ADAMTS-5 inhibitory agent and particularly an agent capable of inhibiting the aggrecanase activity of ADAMTS-5.
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申请公布号 |
US7390833(B2) |
申请公布日期 |
2008.06.24 |
申请号 |
US20040983981 |
申请日期 |
2004.11.08 |
申请人 |
WYETH |
发明人 |
MORRIS ELISABETH A.;GLASSON SONYA;XIANG JASON SHAOYUN |
分类号 |
A01N41/02;A01N37/12;A01N37/30;A01N37/34;A01N37/44;A61K31/195;A61K31/205;A61K31/255;A61K31/275;C07C311/29;C07C311/46;C07D213/30;C07D213/64;C07D213/643;C07D215/14;C07D215/22;C07D215/227;C07D215/233;C07D217/18;C07D235/12;C07D239/34;C07D239/60;C07D261/14;C07D263/22;C07D263/58;C07D277/64;C07D277/68;C07D295/096;C07D295/192;C07D307/79;C07D307/80;C07D307/82;C07D307/84;C07D319/18;C07D321/10;C07D333/20;C07D333/36;C07D333/66 |
主分类号 |
A01N41/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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