| 摘要 |
There are described compounds of general formula (I) and isomeric forms t hereof wherein n is 0,1,2 or 3, saturated or unsaturated; most preferably at least one of R1 to R5 represents halogen; at least one of R1, R2, R3, R4 an d R5 is selected from -S-R or -COOR, or two or more Of R1-R5 comprise a link ing group such as -S-(CH2)mS-, where m is 1, 2 or 3 and R is selected from a lkyl having 1 to 5 carbon atoms, cycloalkyl having 3-6 carbon atoms, hydroxy , and aryl having 6 to 10 carbon atoms, such groups being optionally substit uted, and when R1 is selected from -S-R, then at least one of R2, R3 and R5 is most preferably selected from halogen; and R1, R2, R3, R4 and R5 are othe rwise the same or different and are selected from hydrogen, halogen, alkyl h aving 1 to 5 carbon atoms, electron donor groups such as alkoxy having 1-5 c arbon atoms or hydroxy, electron acceptor groups selected from cyano, nitro, trifluoroalkyl or amide; alkylamino, benzoyloxy, nitroxy, phenyl or sulpho; and pharmacologically acceptable salts thereof. Compounds described have ac tivity on the melanocortin receptors and have application in the treatment o f a wide range of inflammatory, arthritic or central nerve regeneration cond itions.
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