发明名称 |
TRPV1+ SENSORY NEURONS CONTROL OF BETA-CELL STRESS AND ISLETINFLAMMATION IN DIABETES |
摘要 |
A process is disclosed for controlling inflammatory tissue access through release of neuropeptides, such as substance P (sP), to insulin-responsive s ensory neurons, whereby simultaneous control of insulin sensitivity/resistan ce is manifested. In models of Type 1 and Type 2 diabetes, sensory afferents , in particular TRPV1, have fundamental roles in insulin/glucose homeostasis , islet physiology and autoimmune tissue inflammation. By manipulation of th e TRPV1 neuro-.beta.-cell circuit or enhancement of pancreatic sP levels, no rmalization of insulin resistance, clearance of inflammation and prevention of both Type 1 and Type 2 diabetes is realized.
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申请公布号 |
CA2672490(A1) |
申请公布日期 |
2008.06.19 |
申请号 |
CA20072672490 |
申请日期 |
2007.12.13 |
申请人 |
THE HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE |
发明人 |
SALTER, MICHAEL;TANG, LAN;DOSCH, HANS-MICHAEL;CHAN, YIN;RAZAVI-DRAKHSHI, ROZITA |
分类号 |
A61K38/08;A61K38/02;A61P3/10 |
主分类号 |
A61K38/08 |
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