METHODS FOR IMPROVING ANTIBODY PRODUCTION

摘要

The present invention encompasses manufacturing of antibody variants, such as variant of huC242, or fragments thereof, wherein the variants are manufactured by substituting one or more amino acid residues in a parent antibody. Such substitution(s) is preferably done in a variable region framework sequence of the parent antibody comprising a heavy and a light chain. As a consequence of such substitution(s), variant antibodies or fragments thereof show enhanced antibody synthesis when introduced in a host cell as compared to the parent antibody.