PROCESS FOR PREPARING INSTANT FORMS OF AQUEOUS MIXED MICELLAR SOLUTIONS AS PHYSIOLOGICAL BUFFER SYSTEMS FOR USE IN THE ANALYSIS OF IN VITRO RELEASE

摘要

The invention relates to a process for preparing instant forms of aqueous mixed micellar solutions containing phospholipid and non-phospholipid components, particularly FaSSIF Instant, FeSSIF Instant and FeSSIFplus Instant, which are sufficiently stable for storage, comprising preparing a concentrated aqueous mixed micellar solution and subsequently eliminating the solvent under reduced pressure, by lyophilisation or spray drying, using no organic solvent in any of the process steps. The redispersed aqueous mixed micellar solutions are needed particularly for use in the analysis of in vitro release as physiological buffer systems for predicting the in vivo resorption of pharmaceutical active substances.