| 发明名称 |
METHODS FOR PROTECTING ALLOGENEIC ISLET TRANSPLANT USING SOLUBLE CTLA4 MUTANT MOLECULES |
| 摘要 |
The present invention is a method of inhibiting islet cell transplant rejection, particularly to treat diabetes, such as type-1 and type-2 diabetes, by administering to a subject an effective amount of a soluble CTLA4 mutant molecule. One example of a soluble CTLA4 mutant molecule is L104EA29YIg.
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| 申请公布号 |
PT1397153(E) |
申请公布日期 |
2008.06.12 |
| 申请号 |
PT20020734556T |
申请日期 |
2002.05.23 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
CHRISTIAN P. LARSEN;THOMAS C. PEARSON;ANDREW B. ADAMS |
| 分类号 |
A61K38/17;C12N15/09;A61K31/436;A61K38/00;A61K45/00;A61P1/04;A61P1/16;A61P3/10;A61P7/04;A61P13/12;A61P17/06;A61P17/12;A61P19/02;A61P21/04;A61P25/00;A61P27/02;A61P29/00;A61P35/00;A61P35/02;A61P37/02;A61P37/06;A61P43/00;C07K14/705 |
主分类号 |
A61K38/17 |
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