发明名称 Process for the Purification of Perindopril
摘要 A dicyclohexyamine salt of compound of formula I, namely perindopril, having an X-ray powder diffraction pattern with characteristic peaks (2theta): 8.462, 10.624, 18.693, 9.424, 17.272, 14.177, 19.499, 20.765, 21.409, and 14.540. A process for preparation of the said salt of perindopril and its use in the purification of an impure perindopril and a process for purification of perindropril comprising formation of its salt with dicyclohexylamine. The present invention also relates to preparation of Perindopril tert-butyl amine salt directly from Perindopril dicyclohexylamine salt without isolating the free base.
申请公布号 US2008139823(A1) 申请公布日期 2008.06.12
申请号 US20050886382 申请日期 2005.06.09
申请人 LUPIN LIMITED 发明人 SINGH GIRIJ PAL;GODBOLE HIMANSHU MADHAV;RANANAWARE UMESH BABANRAO;DHAKE VILAS NATHU;TAMBE SUHAS GANPAT;NEHATE SAGAR PURUSHOTTAM
分类号 C07D209/42 主分类号 C07D209/42
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