METHOD

摘要

The present invention relates to an assay method for identifying an agent that is taken up and retained intracellularly in lung tissue comprising the steps of: (a) contacting a test sample comprising a lung transporter protein with an agent that acts on an intracellular target in the lung; (b) identifying an agent that is a substrate for the lung transporter protein; and (c) measuring the retention time of the agent in the lung tissue, wherein a retention time of at least 0.5 hours is indicative of an agent that is retained in the lung tissue.