The instant invention provides for substituted naphthyridine compounds th at inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for comp ositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
申请公布号
CA2670760(A1)
申请公布日期
2008.06.12
申请号
CA20072670760
申请日期
2007.12.03
申请人
BANYU PHARMACEUTICAL CO., LTD.;MERCK & CO., INC.
发明人
WANG, JIABING;SANDERSON, PHILIP E.;ONOZAKI, YU;OGINO, YOSHIO;LIQUORI, MICHAEL E.;LAYTON, MARK E.;KELLY, MICHAEL J., III