<p>Pharmaceutical compositions for buccal delivery of zolpidem comprising an effective amount of zolpidem and a carbonate and bicarbonate buffer system in an amount sufficient to raise the pH of saliva to at least 8.5 irrespective of starting pH, and wherein the carbonate forms a coating on the bicarbonate wherein the amount of carbonate coating is at least 30% (w/w) of the total buffer amount are described. Methods of treating insomnia in a subject are described, the method including the step of administering to the subject the pharmaceutical composition of the present invention, wherein the administering is on an as-needed basis. Method of treating MOTN insomnia in a subject are also described.</p>
申请公布号
WO2008067549(A2)
申请公布日期
2008.06.05
申请号
WO2007US86136
申请日期
2007.11.30
申请人
TRANSCEPT PHARMACEUTICALS, INC.;SPI PHARMA, INC.;PATHER, SATHASIVAN, INDIRAN;SINGH, NIKHILESH;KAVALAKATT, PAULY;ADAIR, DENNIS
发明人
PATHER, SATHASIVAN, INDIRAN;SINGH, NIKHILESH;KAVALAKATT, PAULY;ADAIR, DENNIS