COMPOSITIONS AND METHODS FOR TREATING CANCER

摘要

This present invention relates compositions and methods of treating cancer and methods of accessing/monitoring the responsiveness of a cancer cell to a therapeutic compound, specific for a DNA repair pathway. A method for treating cancer is provided, which includes: a) determining whether the cancer cell is deficient in a DNA repair pathway (eg. Fanconi anemia) and b) administering a DNA damaging agent or inhibitor specific for at least one different DNA repair pathway than that identified in step (a) (eg. mismatch repair or non-homologous endjoining repair pathways).