发明名称 |
Nucleic acids encoding estrogen receptor ligand binding domain variants |
摘要 |
Mutants of steroid receptor ligand binding domains and synthetic ligands which have specific binding affinities for these receptors are provided. The use of these LBD-ligand combinations for construction of selective "molecular gene switches" is disclosed. Methods of regulating gene function using these switches are provided.
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申请公布号 |
US7381813(B2) |
申请公布日期 |
2008.06.03 |
申请号 |
US20020157899 |
申请日期 |
2002.05.31 |
申请人 |
NOVARTIS AG |
发明人 |
BRACKEN KATHRYN RENE;DE LOS ANGELES JOSEPH ERNEST;HUANG YING;KADAN MICHAEL JOSEPH;KSANDER GARY MICHAEL;ZERBY DENNIS BRYAN |
分类号 |
C07H21/04;C12N15/09;A61K31/138;A61K31/27;A61K31/5375;A61P17/00;A61P17/06;A61P35/00;A61P37/06;C07C217/20;C07C271/16;C07D295/08;C07H21/02;C07K14/435;C07K14/47;C07K14/705;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/00 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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地址 |
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