发明名称 |
FORMA SOLIDA DE DOSIFICACION FARMACEUTICA DE ADMINISTRACION ORAL, QUE COMPRENDE UNA FORMA CRISTALINA O AMORFA DE UN COMPUESTO MICROINCLUIDO EN UN POLIMERO IONICO INSOLUBLE EN AGUA EN PROPORCION 5:1 A 1:5; Y METODO DE PREPARACION. |
摘要 |
The present invention provides novel pharmaceutical solid dosage forms for oral administration comprising a therapeutically effective amount of an unstable crystalline form or an amorphous form of a therapeutically effective compound micro-embedded into an ionic water-insoluble polymer. The therapeutically effective compounds, which have a tendency to gel, are micro-embedded into an ionic water-insoluble polymer matrix to provide a dosage form having rapid, reproducible, and complete dissolution profiles. These novel solid pharmaceutical dosage forms are useful in the treatment or control of a number of diseases. The present invention also provides a method for treating a disease comprising administering to a subject, in need thereof, a therapeutically effective amount of the novel solid pharmaceutical dosage form. The present invention further provides a method for preparing the pharmaceutical dosage forms. |
申请公布号 |
CL2007002921(A1) |
申请公布日期 |
2008.05.30 |
申请号 |
CL20070002921 |
申请日期 |
2007.10.11 |
申请人 |
F. HOFFMANN-LA ROCHE AG. |
发明人 |
ANTONIO A. ALBANO, WANTANEE PHUAPRADIT, NAVNIT HARGOVINDAS SHAH, ZHONGSHUI YU Y LIN ZHANG. |
分类号 |
A61K9/00;A61K31/4965 |
主分类号 |
A61K9/00 |
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