发明名称 |
ANTI-SENSE OLIGONUCLEOTIDE FOR GENE SILENCING OF PACSIN-3 AND COMPOSITION FOR SUPPRESSING NKT LYMPHOCYTE ACTIVITY COMPRISING IT |
摘要 |
An anti-sense oligonucleotide is provided to induce the gene silencing of PACSIN-3 and inhibit activity of NKT(natural killer T) lymphocyte, so that the oligonucleotide is useful for prevention and treatment of autoimmune disease caused by NKT lymphocyte. A double-stranded siRNA(small interfering RNA) for gene silencing of PACSIN-3 has the nucleotide sequence of SEQ ID NO:5 and forms a hairpin structure in 5-15 bp of loop region. A recombinant viral vector contains the double-stranded siRNA. A method for preventing or treating autoimmune disease comprises the double-stranded siRNA. The in vitro activity of NKT cell is inhibited through down-regulation of the PACSIN-3 gene capable of communicating with CD1d, which transfers a glycolipid antigen to NKT cells, by the double-stranded siRNA of SEQ ID NO:5.
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申请公布号 |
KR100833542(B1) |
申请公布日期 |
2008.05.29 |
申请号 |
KR20060121746 |
申请日期 |
2006.12.04 |
申请人 |
KOREA UNIVERSITY INDUSTRIAL & ACADEMIC COLLABORATION FOUNDATION |
发明人 |
CHUN, TAE HOON;LEE, JAE YEON |
分类号 |
C12N15/10;C12N15/113 |
主分类号 |
C12N15/10 |
代理机构 |
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