QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

摘要

[PROBLEMS] To provide a pharmaceutical agent having a P2Y12 inhibitory activity, particularly a compound useful as a platelet aggregation inhibitor. [MEANS FOR SOLVING PROBLEMS] An extensive study was made on an P2Y12 inhibitor, and it was found that a quinolone derivative having a substituted carbamoyl group at position-3 wherein the substituent on the carbamoyl group is -(polymethylene in which a carbon atom adjacent to the carbamoyl group is substituted)-CO<SUB>2</SUB>R (wherein R represents -H or a lower alkyl) has an excellent platelet aggregation inhibitory activity and has improved in vivo kinetics. The compound is excellent in P2Y12 inhibitory activity and platelet aggregation inhibitory activity, and is therefore useful as a platelet aggregation inhibitor.