发明名称 |
BETULINIC ACID, DERIVATIVES AND ANALOGS THEREOF AND USES THEREFOR |
摘要 |
<p>Provided herein provided herein are novel analogs and derivatives of betulinic acid. Also provided is a method for inhibiting an activity of one or more specificity protein (Sp) transcription factors cells associated with a neoplastic disease using betulinic acid, betulinic acid analog(s) and/or derivative(s) effective to decrease expression of a microRNA with concomitant increase in Sp suppressor gene expession. The betulinic acid analogs and derivatives also are effective in methods provided herein for inhibiting proliferation of cells associated with a neoplastic disease for treating a cancer or for reducing toxicity of a cancer therapy in a subject via administration of an analog or derivative of betulinic acid and, optionally, another anticancer drug.</p> |
申请公布号 |
WO2008063318(A2) |
申请公布日期 |
2008.05.29 |
申请号 |
WO2007US21828 |
申请日期 |
2007.10.12 |
申请人 |
THE TEXAS A & M UNIVERSITY SYSTEM AND SAFE ET AL |
发明人 |
SAFE, STEPHEN, H.;CHINTHARLAPALLI, SUDHAKAR |
分类号 |
A61K31/56 |
主分类号 |
A61K31/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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