发明名称 |
ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ НА ОСНОВЕ ЛИШАЙНИКА БОРОДАТОГО (USNEA BARBATA) И ЗВЕРОБОЯ ОБЫКНОВЕННОГО(HYPERICUM PERFORATUM) И ИХ ПРИМЕНЕНИЕ |
摘要 |
New pharmaceutical compositions (A) contain 0.01-20 (preferably 0.11-20, especially 0.5-5) wt. % beard lichen ( Usnea barbata) extract (I) and 0.01-80 (preferably 0.11-20, especially 0.5-5) wt. % St. John's wort ( Hypericum perforatum) extract (II). ACTIVITY : Antiseborrheic; Dermatological; Vulnerary; Antiinflammatory; Antibacterial; Fungicide; Antipsoriatic. MECHANISM OF ACTION : UV-induced collagenase activation inhibitor; UV-induced prostaglandin E 2 synthesis inhibitor. In tests in primary human fibroblast cultures, the active collagenase (MMP-1) content (initially ca. 3.0 ng/ml) was increased to ca. 8.0 ng/ml by UVA-1 irradiation (60 J/cm 2>) to ca. 8 ng/ml; and on subsequent incubation for 24 hours with Usnea barbata extract (0.1 v/v) or a combination of the Usnea barbata extract (0.1 v/v) and Hypericum perforatum extract (0.1 v/v) was reduced to ca. 5.2 ng/ml or ca. 0.8 ng/ml respectively. |
申请公布号 |
RU2006140864(A) |
申请公布日期 |
2008.05.27 |
申请号 |
RU20060140864 |
申请日期 |
2005.04.07 |
申请人 |
УНИВЕРЗИТЭТСКЛИНИКУМ ФРАЙБУРГ (DE) |
发明人 |
ШЕМПП Кристоф (DE);ЙОХЕР Андреа (DE);ЭНГЕЛЬ Катрин (DE);ХУЙКЕ Констансе (DE) |
分类号 |
A61K36/09;A61K9/00;A61K9/06;A61K36/38;A61K47/10;A61P17/08 |
主分类号 |
A61K36/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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