发明名称 METABOTROPIC GABA[B] RECEPTORS, RECEPTOR-SPECIFIC LIGANDS AND THEIR USES
摘要 <P>PROBLEM TO BE SOLVED: To provide purified GABA<SB>B</SB>receptors, receptor proteins, and nucleic acids which encode such proteins, to provide methods for isolating other members of the GABA<SB>B</SB>receptor family using a DNA cloning technology and probes derived from the sequences, to provide novel members of the GABA<SB>B</SB>receptor family isolated by such methods, and to further provide the use of the GABA<SB>B</SB>receptors and receptor proteins and cells transformed with a gene encoding a GABA<SB>B</SB>receptor protein in identifying and characterizing compounds which modulate the activity of the GABA<SB>B</SB>receptor. <P>SOLUTION: Purified GABA<SB>B</SB>receptors and receptor proteins having significant homology with the GABA<SB>B</SB>receptors and a DNAs encoding the receptors are provided. <P>COPYRIGHT: (C)2008,JPO&INPIT
申请公布号 JP2008113662(A) 申请公布日期 2008.05.22
申请号 JP20070291036 申请日期 2007.11.08
申请人 NOVARTIS AG 发明人 KAUPMANN KLEMENS;BETTLER BERNHARD;BITTIGER HELMUT;FROESTL WOLFGANG;MICKEL STUART JOHN
分类号 A01K67/027;C12N15/09;A61K38/00;C07F9/30;C07K14/705;C07K16/28;C07K16/46;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/12;C12P21/08;C12Q1/68;G01N33/15;G01N33/50;G01N33/53 主分类号 A01K67/027
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