DIPHYLLIN AND OTHER LIGNANS AS A MEDICAMENT FOR V-ATPASE MEDIATED DISEASE

摘要

A V-ATPase or gastric proton pump inhibiting lignan such as diphyllin and related glycosides and derivatives, for use as a medicament in the treatment of excessive osteoclast action or in the treatment of excessive gastric acidification, suitably of the general formula: wherein : R^b and R^c may together form an alkylene bridge; R^d and R^e also may together form an alkylene bridge; and each dotted bond independently is present or absent; and wherein the lactone ring is optionally opened and is optionally esterified.