发明名称 |
NOVEL INHIBITORS OF GLUTAMINYL CYCLASE |
摘要 |
<p>The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof wherein R<SUP>1</SUP> represents heteroaryl; -carbocyclyl-heteroaryl; -alkenylheteroaryl or -alkylheteroaryl; R<SUP>2</SUP> represents alkyl, which may optionally be substituted by hydroxy; carbocyclyl, which may optionally be substituted by one or more groups selected from alkyl and hydroxy; aryl; -aryl-heteroaryl; -heteroaryl-aryl; -aryl-heterocyclyl; H; heteroaryl; or heterocyclyl, which may optionally be substituted by one or more groups selected from alkyl, oxo and hydroxy; R<SUP>3</SUP> <SUP/>represe</p> |
申请公布号 |
WO2008055947(A1) |
申请公布日期 |
2008.05.15 |
申请号 |
WO2007EP62034 |
申请日期 |
2007.11.08 |
申请人 |
PROBIODRUG AG;THORMANN, MICHAEL;ALMSTETTER, MICHAEL;TREML, ANDREAS;HEISER, ULRICH;BUCHHOLZ, MIRKO |
发明人 |
THORMANN, MICHAEL;ALMSTETTER, MICHAEL;TREML, ANDREAS;HEISER, ULRICH;BUCHHOLZ, MIRKO |
分类号 |
C07D401/14;A61K31/4025;A61P25/14;A61P25/28;C07D403/06;C07D403/14;C07D405/14;C07D413/14;C07D417/14 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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