发明名称 |
PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS |
摘要 |
Compounds are described which inhibit mitogen activated protein kinase-activated protein kinase-2 (MK-2). Methods of making such compounds are described, as well as a method of using them for the inhibition of MK-2, and for the prevention or treatment of a disease or disorder that is mediated by TNFalpha, where the method involves administering to the subject an MK-2 inhibiting compound of the present invention. Pharmaceutical compositions and kits which contain the present MK-2 inhibiting compounds are also described.
|
申请公布号 |
US2008113971(A1) |
申请公布日期 |
2008.05.15 |
申请号 |
US20070958229 |
申请日期 |
2007.12.17 |
申请人 |
|
发明人 |
HANAU CATHLEEN E.;MERSHON SERENA M.;GRANETO MATTHEW J.;MEYERS MARVIN J.;BUCHLER INGRID P.;HEGDE SHRIDHAR G.;WU KUN K.;LIU SHUANG |
分类号 |
A61K31/551;A61K31/498;C07D487/04 |
主分类号 |
A61K31/551 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|