| 发明名称 |
N-(2-ARYLETHYL) BENZYLAMINE ALS 5-HT6 REZEPTOR-ANTAGONISTE |
| 摘要 |
The present invention provides compounds of formula I pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are antagonists of the 5-HT<SUB>6 </SUB>receptor. The present invention further provides a method of treating disorders associated with 5-HT<SUB>6 </SUB>receptors, including schizophrenia, anxiety, Alzheimer's disease, and cognitive disorders selected from the group consisting of age-related cognitive decline, mild cognitive impairment, and dementia, comprising: administering to a patient in need thereof an effective amount of a compound of formula I. |
| 申请公布号 |
DE60222396(T2) |
申请公布日期 |
2008.05.15 |
| 申请号 |
DE2002622396T |
申请日期 |
2002.03.15 |
| 申请人 |
ELI LILLY AND CO. |
发明人 |
CHEN, ZHAOGEN;COHEN, MICHAEL PHILIP;FISHER, MATTHEW JOSEPH;GIETHLEN, BRUNO;GILLIG, JAMES RONALD;MCCOWAN, JEFFERSON RAY;MILLER, SHAWN CHRISTOPHER;SCHAUS, JOHN MEHNERT |
| 分类号 |
A61K31/4045;C07D233/64;A61K31/137;A61K31/18;A61K31/343;A61K31/381;A61K31/417;A61K31/426;A61K31/427;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/4439;A61K31/505;A61K31/506;A61P25/18;A61P25/22;A61P25/28;C07C211/52;C07C211/56;C07C215/32;C07C215/50;C07C217/54;C07C217/58;C07C217/60;C07C225/16;C07C309/73;C07C311/37;C07C317/32;C07C317/34;C07C323/01;C07C323/32;C07D209/00;C07D209/08;C07D209/14;C07D209/16;C07D209/86;C07D213/30;C07D213/38;C07D213/63;C07D213/64;C07D213/65;C07D213/68;C07D213/74;C07D233/24;C07D239/34;C07D277/20;C07D277/34;C07D307/91;C07D333/20;C07D401/12;C07D403/06;C07D403/12;C07D405/12;C07D417/12;C07D471/04;C07F7/08 |
主分类号 |
A61K31/4045 |
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