发明名称 |
Cloning and expression of the full length 110 kDa antigen of Orientia tsutsugamushi to be used as a vaccine component against scrub typhus |
摘要 |
The inventive subject matter relates to a recombinant 110 kDa protein from O. tsutsugamuchi, Karp, Kato and Gilliam strains and for a DNA expression system containing DNA encoding the 110 kDa protein of O. tsutsugamuchi. The invention also relates to the use of these recombinant contructs in a formulation for the induction of a protective immune response against O. tsutsugamuchi invection using. The inventive subject matter also relates to a recombinant 110 kDa O. tsutsugamuchi protein or 110 kDa fragments for the production of antigen for use in immunodiagnosistic asssays for scrub typhus.
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申请公布号 |
US7371821(B2) |
申请公布日期 |
2008.05.13 |
申请号 |
US20050108867 |
申请日期 |
2005.04.19 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY |
发明人 |
CHING WEI-MEI;CHAO CHIEN-CHUNG |
分类号 |
C07K1/00;A61K38/00;A61K38/19;A61K38/20;A61K39/02;A61K48/00;C07K2/00;C07K14/29;C12N15/00;C12N15/74 |
主分类号 |
C07K1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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