发明名称 |
Heterologous G-Csf Fusion Proteins |
摘要 |
The present invention encompasses heterologous fusion 5 proteins comprising a hyperglycsoylated G-CSF analog fused to proteins such as albumin and the Fc portion of animmunoglobulin which act to extend the in vivo half-life of the protein compared to native G-CSF. These fusion proteins are particularly suited for the treatment of conditions 10 treatable by stimulation of circulating neutrophils, such as after chemotherapy regimens or in chronic congenital neutropenia.
|
申请公布号 |
US2008108560(A1) |
申请公布日期 |
2008.05.08 |
申请号 |
US20030506455 |
申请日期 |
2003.02.21 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
BEALS JOHN MICHAEL;KUCHIBHOTLA UMA |
分类号 |
A61K38/00;A61P43/00;C07H21/04;C07K14/535;C07K14/765;C07K16/00;C12N5/04;C12N15/00 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|