发明名称 |
Production method of optically active 2- [ (N-Benzylprolyl) Amino ] Benzophenone compound |
摘要 |
<p>The present invention relates to a production method of optically active 2-[(N-benzylprolyl)amino]-5-chlorobenzophenone (3) or a salt thereof, which includes reacting optically active N-benzylproline (1) with 2-amino-5-chlorobenzophenone (2) in acetonitrile and in the presence of an amide compound and thionyl chloride. According to the method of the present invention, optically active 2-[(N-benzylprolyl)amino]-5-chlorobenzophenone (3) or a salt thereof can be conveniently produced at a high purity and in a high yield:
wherein * shows an asymmetric carbon atom and the configuration of the asymmetric carbon atom is S or R.</p> |
申请公布号 |
EP1918276(A1) |
申请公布日期 |
2008.05.07 |
申请号 |
EP20070254350 |
申请日期 |
2007.11.02 |
申请人 |
AJINOMOTO CO., INC. |
发明人 |
HAMADA, TAKAYUKI;IZAWA, KUNISUKE;SOLOSHONOK, VADIM A. |
分类号 |
C07D207/16 |
主分类号 |
C07D207/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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