摘要 |
A process for the preparation of pure Duloxetine hydrochloride comprises the steps of : a) reacting 1-(thiophen-2-yl)ethanone with dimethylamine hydrochloride, b) purifying the component in a solvent, c) reducing the component with an alkali metal borohydride, d) resolving the compound with a chiral acid, and treating the obtained compound with weak inorganic base, e) reacting the compound to give Duloxetine oxalate salt and f) converting the Duloxetine salt into its hydrochloride salt. Further the purifications of the obtained compound and of two intermediate products are described. |
申请人 |
MSN LABORATORIES LIMITED;SATYANARAYANA REDDY, MANNE;KISHORE KUMAR, MUPPA;THIRUMALAI RAJAN, SRINIVASAN;SHYLA PRASAD, DURGADAS |
发明人 |
SATYANARAYANA REDDY, MANNE;KISHORE KUMAR, MUPPA;THIRUMALAI RAJAN, SRINIVASAN;SHYLA PRASAD, DURGADAS |