| 发明名称 |
PROTEASE RESISTANT MUTANTS OF STROMAL CELL DERIVED FACTOR-1 IN THE REPAIR OF TISSUE DAMAGE |
| 摘要 |
The present invention is directed stromal cell derived factor-1 peptides that have been mutated to make them resistant to digestion by the proteases dipeptidyl peptidase IV (DPPIV) and matrix metalloproteinase-2 (MMP-2) but which maintain the ability of native SDF-I to attract T cells. The mutants may be attached to membranes formed by self-assembling peptides and then implanted at sites of tissue damage to help promote repair. |
| 申请公布号 |
WO2008051505(A2) |
申请公布日期 |
2008.05.02 |
| 申请号 |
WO2007US22394 |
申请日期 |
2007.10.22 |
| 申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;LEE, RICHARD;SEGERS, VINCENT |
发明人 |
LEE, RICHARD;SEGERS, VINCENT |
| 分类号 |
A61K38/00;A61K38/48;A61P43/00;C07H21/04;C07K16/00;C12N9/50 |
主分类号 |
A61K38/00 |
| 代理机构 |
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