| 摘要 |
The present invention provides LHRH analogues and LHRH antagonists for use in the treatment or prophylaxis of hormone-dependent cancers, in particular prostate can- cer, prostate carcinoma and/or advanced prostate carcinoma, wherein the treatment comprises the steps a) administering an initial dose of an LHRH analogue over a first period, the dose being sufficient to effect hormonal castration, b) then, administering a maintenance dose of an LHRH antagonist over a second period, the dose being insuf- ficient to achieve and/or maintain hormonal castration, c) optionally, repeating steps a) and b). The present invention further provides pharmaceutical kits that comprise one or more initial doses of an LHRH analogue in one or more containers, each in an amount sufficient to effect hormonal castration, and one or more maintenance doses of an LHRH antagonist in one or more containers, each in an amount insufficient to achieve and/or maintain hormonal castration. |
