Methods for diagnosing a neurodegenerative condition

摘要

A non-invasive method of diagnosing an amyloidogenic disorder, or a predisposition thereto, in a mammal, said method being characterised by:
illuminating a mammalian ocular lens with an excitation light beam;
detecting light signals emitted from the supranuclear or cortical region of said lens; and
analysing said detected light signals by quasi-elastic light scattering (QLS), Raman spectroscopy or fluorimetry to detect protein aggregates in said supranuclear or cortical region;
wherein the presence or an increase in the amount of aggregates in said region as compared with a normal control value indicates that said mammal is suffering from or is at risk of developing an amyloidogenic disorder.