发明名称 |
Anti-CD40 antibodies capable of blocking B-cell activation |
摘要 |
Methods for preventing or treating an antibody-mediated disease in a patient are presented, the methods comprising administration of a monoclonal antibody capable of binding to a human CD40 antigen located on the surface of a human B cell, wherein the binding of the antibody to the CD40 antigen prevents the growth or differentiation of the B cell. Monoclonal antibodies useful in these methods, and epitopes immunoreactive with such monoclonal antibodies are also presented.
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申请公布号 |
US7361345(B2) |
申请公布日期 |
2008.04.22 |
申请号 |
US20050053536 |
申请日期 |
2005.02.07 |
申请人 |
NOVARTIS VACCINES AND DIAGNOSTICS, INC. |
发明人 |
DE BOER MARK;CONROY LEAH B. |
分类号 |
A61K39/395;C12N15/02;A61K31/4353;A61K31/436;A61K31/573;A61K38/00;A61K45/00;A61P1/16;A61P7/06;A61P29/00;A61P37/02;A61P37/06;A61P37/08;A61P43/00;C07K14/705;C07K16/00;C07K16/28;C12N5/10;C12N5/12;C12N15/06;C12N15/09;C12P21/02;C12P21/08;G01N33/53;G01N33/531 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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