ISOLATED POLYPEPTIDE POSSESSING ANTIVIRAL ACTIVITY (VARIANTS), POLYNUCLEOTIDE ENCODING ITS (VARIANTS), EXPRESSING VECTOR, RECOMBINANT CELL-HOST, METHOD FOR PREPARING POLYPEPTIDE, ANTIBODY SPECIFIC TO POLYPEPTIDE AND POLYPEPTIDE-CONTAINING PHARMACEUTICAL COMPOSITION

摘要

FIELD: biotechnology, molecular biology, proteins. ^ SUBSTANCE: invention relates to a method for preparing cytokines of class II and can be used in medicine. Prepared proteins zcyto20, zcyto22, zcyto24 and zcyto25 are the most relative with interferon-alpha at amino acid sequence level. Receptor of cytokines of class II represents a receptor for this family of proteins. Proteins can be prepared by recombinant way using a cell-host transformed with expression vector that comprises nucleic acids corresponding to proteins. Base on proteins xcyto20, xcyto21, zcyto22, zcyto24 and zcyto25 antiviral pharmaceutical composition and specific antibodies are prepared. Invention provides preparing the novel cytokine that stimulates cells of differentiation hemopoietic line and possesses the expressed antiviral activity. ^ EFFECT: valuable biological and medicinal properties of polypeptide, improved preparing method. ^ 24 cl, 21 tbl, 32 ex