MEDICAL EMULSION OF PERFLUORORGANIC COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF

摘要

The invention relates to medicine, in particular to medications for treating blood losses, hypoxic and ishemic states, for improving a blood oxygen supply and for preserving isolated perfused organs and tissues. The inventive medical emulsion of perfluororganic compounds comprises rapidly excretable perfluororganic compounds such as perfluordecalin, perfluoractilbromide, a perfluororganic additive embodied in the form of a mixture of perfluorinated tertiary amines and phospholipids in the form of a water-salt dispersion. Said perfluordecalin and perfluoractilbromide are contained in the composition of the rapidly excretable perfluororganic compounds at a ratio ranging from 10:1 to 1:10. The mixture of perfluorinated tertiary amines is embodied in the form of the mixture of perfluorotripropylamine and the coproducts thereof: cis- and trans-isomers perfluor-1-propyl 3,4-dimethylpirrolidone and perfluor-1-propyl-4-methhylpiperidine. The inventive method for producing the emulsion consists in producing the water-salt dispersion of phospholipids, in homogenising the perfluororganic compounds therein at a high pressure and in hear sterilisation of the final emulsion. The storage life of the inventive emulsion in the unfrozen state thereof at a temperature of +4 DEG C is equal to at least 6 months during which the biocompatibility of said emulsion with a biological medium (blood, plasma or serum) is preserved.