发明名称 |
PROCESSES FOR THE PREPARATION OF SUBSTITUTED 2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLE-1,3-DIONE |
摘要 |
The present invention provides processes for the preparation of substituted 2-(2,6- dioxopiperidin-3-yl)isoindole-l,3-diones which are useful, for example, for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-a.The invention can provide cost-effective and efficient processes for the commercial production of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-l,3-diones, including, but not limited to, 4- [(N,N-dimethylhydrazono)methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1.3-dione, 4-aminornethyl-2-(2,6-dioxopiperidin-3-yl)isoindole-l,3-dione, and 4-[(acylamino)methyl]-2- (2,6-dioxopiperidin-3-yl)isoindole-l,3-diones. |
申请公布号 |
WO2007136640(A3) |
申请公布日期 |
2008.04.10 |
申请号 |
WO2007US11696 |
申请日期 |
2007.05.15 |
申请人 |
CELGENE CORPORATION;MULLER, GEORGE, W.;SAINDANE, MANOHAR;GE, CHUANSHENG;KOTHARE, MOHIT, ATUL;CAMERON, LOUISE, MICHELLE;ROGERS, MARK, EDWARD |
发明人 |
MULLER, GEORGE, W.;SAINDANE, MANOHAR;GE, CHUANSHENG;KOTHARE, MOHIT, ATUL;CAMERON, LOUISE, MICHELLE;ROGERS, MARK, EDWARD |
分类号 |
C07D401/04;C07D307/89 |
主分类号 |
C07D401/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|