| 摘要 |
The present invention provides benzamide inhibitors of the P2Xreceptor of the formula (I), wherein Rand Rare as defined in claim 1. Ris a nitrogen linked (С-С) heterocyclyl of formula (II), wherein Rand Rare as defined in claim 1. The compounds of the invention are useful in the treatment of IL-1 mediated disorders, including, without limitation, inflammatory diseases such as osteoarthritis and rheumatoid arthritis; allergies, asthma, COPD, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.(І)(ІІ) |
