ANTIOXIDANT PROTEIN, COMPOSITIONS, AND METHODS OF USE

摘要

The present invention provides a novel antioxidant protein (SAOP) comprising a MOCO Sulfurase C-terminal Domain (MOSC), which may be secreted and which has antioxidant activity, as demonstrated by its ability to protect cultured cells from oxidative stress, and by its ability to increase GSH concentration. The present invention also provides polynucleotides encoding the antioxidant protein, as well as vectors containing the polynucleotide under control of regulatory sequences, and corresponding host cells. The present invention also provides a composition comprising an effective amount of the antioxidant protein with a pharmaceutically acceptable carrier or excipient. The composition finds use in ameliorating oxidative stress in a mammal, and thus is useful for treating conditions characterized by or associated with oxidative stress. The present invention further provides an antibody or antigen-binding fragment that binds specifically to the antioxidant protein of the invention, which finds use in various diagnostic applications for oxidative stress.