Therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia

摘要

The present invention provides a therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia comprising, as an active ingredient, a tricyclic compound represented by formula (I): [wherein R¹ represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy or halogen; X¹-X²-X³ represents CR⁵-CR⁶-CR⁷-CR⁸, N(O)_m-CR⁶-CR⁷-CR⁸, CR⁵-CR⁶-N(O)_m-CR⁸, CR⁵-CR⁶-CR⁷-N(O)_m, CR⁵-CR⁶-O, CR⁵-CR⁶-S, O-CR⁷-CR⁸, S-CR⁷-CR⁸ or O-CR⁷-N; Y represents CH₂S-, -CH₂SO-, -CH₂SO₂-, -CH₂O-, -CH-CH-, -(CH₂)_p-, -SCH₂-, -SOCH₂-, -SO₂CH₂- or -OCH₂-; and R² represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkoxy, amino, mono(substituted or unsubstituted lower alkyl)-substituted amino, di(substituted or unsubstituted lower alkyl)-substituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkylamino, substituted or unsubstituted arylamino or a substituted or unsubstituted heteroalicyclic group] or a pharmaceutically acceptable salt thereof.