METHOD FOR THERAPY FOR B-CELL MALIGNANCY USING ANTAGONIST ANTI-CD40 ANTIBODY

摘要

PROBLEM TO BE SOLVED: To provide a method for therapy for B-cell malignancy.

SOLUTION: The method for therapy for B-cell malignancy is provided. The method comprises a process for administration of a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity when the antibody binds a CD40 antigen on a normal human B cell, exhibits antagonist activity when the antibody binds a CD40 antigen on a malignant human B cell, and can exhibit antagonist activity when the antibody binds a CD40 antigen on a normal human B cells. Antagonist activity of the anti-C antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of malignant human B cells.

COPYRIGHT: (C)2008,JPO&INPIT