发明名称 |
Method and probe for identifying bacterial virulence modifying agents, agents thus identified, and their use |
摘要 |
A method for identifying antibacterial agents comprises depleting bacteria of a strain comprising a luxAB construct of Ca<SUP>2+</SUP>, incubating the Ca<SUP>2+</SUP> depleted bacteria with an agent the antibacterial effect of which shall be determined, recording the light emitted by the bacteria upon addition of an aldehyde, the incubation being carried out at a temperature which is at least 10° C. higher than the temperature at which the light is emitted by the bacteria. Also disclosed are corresponding probes and antibacterial agents identified by the method.
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申请公布号 |
US7351861(B2) |
申请公布日期 |
2008.04.01 |
申请号 |
US20050526461 |
申请日期 |
2005.10.27 |
申请人 |
INNATE PHARMACEUTICALS AB |
发明人 |
KAUPPI ANNA MARIA;ELOFSSON JAN MIKAEL CHRISTIAN;WOLF-WATZ HANS OLOF;NORDFELTH OLOV ROLAND;DAHLGREN MARKUS KRISTOFFER |
分类号 |
C07C233/00;A61K31/15;A61K31/167;C07C235/64;C07C251/86;C07C323/42;C07D213/88;C07D285/14;C07D307/68;C12Q1/18 |
主分类号 |
C07C233/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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