| 摘要 |
Disclosed is the use of at least one CGRP antagonist compound for the manufacture of a medicament for treating, preventing or remedying psoriasis in a subject. Also disclosed is a method of identifying a candidate compound for use in a medicament for treating psoriasis comprising the steps of: (i) obtaining a compound suspected of binding to a CGRP receptor; (ii) adding the compound at varying concentrations in the range of about 0.1 micromol to 1 millimol to samples comprising CGRP receptors and incubating for a suitable time; (iii) adding labelled CGRP peptide to the incubated samples; (iv) determining the binding of the labelled CGRP peptide to the CGRP receptor in the samples with varying concentrations of the compound; and (v) determining the binding affinity of the compound to the CGRP receptor; whereby a compound that is determined to bind to the CGRP receptor is identified as a candidate compound for use in a medicament for treating psoriasis, wherein said samples comprise live cells having surface bound CGRP receptors. |
