| 摘要 |
<p>This invention relates to processes for the production of 3-oxo-pregnane-21,17-carbolactones of formula (II) as well as 3-oxo-pregn-4-ene-21,17-carbolactones of formula (III) by the metal-free oxidation of 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanes of formula (I). In addition, the invention relates to the dichloromethane hemisolvate of 6?? ,7??; 15??,16??-dimethylene-3-oxo-17??-pregnan-5??-ol-21,17-carbolact one (IV) as such as well as to a process for the production of drospirenone.</p> |
